For endometriosis patients with infertility, oral GnRH antagonists and aromatase inhibitors are promising drugs, especially Elagolix and Letrozole. Letrozole improved the fertility of patients with mild endometriosis. The results of a clinical study of Linzagolix in patients with moderate to severe endometriosis-related pain have not been disclosed yet. Elagolix was approved for the treatment of endometriosis-related pain, but clinical studies of Elagolix for the pretreatment of patients with endometriosis to before In vitro fertilization treatment have not been fulfilled. In clinical trials, Quinagolide showed no statistical difference with the placebo group the results of phase II clinical trial of the IL-33 antibody have not been announced yet clinical trial stage III of vilaprisan was suspended due to drug toxicity. To date, Resveratrol, Bay1316957, and bardoxifene were effective against lesions and pain in controlled animal studies. This paper investigated Genetic changes, estrogen-dependent inflammation induction, progesterone resistance, imbalance in proliferation and apoptosis, angiogenesis, lymphangiogenesis and neurogenesis, and tissue remodeling in its pathogenesis and explored the pharmacological mechanisms, constitutive relationships, and application prospects of each compound in the text. This review aims to present the advances in pathogenesis and the newly reported lead compounds and drugs managing endometriosis. Despite its profound impact on women’s health and quality of life, its pathogenesis has not been fully elucidated, it cannot be cured and the long-term use of drugs yields severe side effects and hinders fertility. The major symptoms are chronic pelvic pain and infertility. 8College of Food and Bioengineering, Xihua University, Chengdu, ChinaĮndometriosis is one of the most common benign gynecological disorders in reproductive-aged women.7Department of Chemistry and Biochemisty, Florida International University, Miami, FL, United States.6Miller School of Medicine, University of Miami, Miami, FL, United States.5Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu, China.4Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China. 3Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu, China.2Personalized Drug Therapy Key Laboratory of Sichuan Province, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.1Department of Pharmacy, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.Jianyou Shi 1,2 †, Xin Tan 1,2 †, Guimei Feng 3,4 †, Yuan Zhuo 5, Zhongliang Jiang 6, Srikanth Banda 7, Lin Wang 8, Wei Zheng 5, Lu Chen 1,2*, Dongke Yu 1,2* and Chun Guo 3,4*
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